Mr. Chow Chiu Lok, Joshua


Although human telomeric DNA sequence does not contain any gene, they have an important role on gene protection while cell division in human.1 It is a familiar object for investigation in the whole word. Typical telomeric sequences are guanine (G)-rich sequences, they can form a special conformation, the G quadruplex. Human telomeric DNA G-quadruplex also is a well-known material for the targeting of cancer and the probing technique. Thus, the excitation dynamics of the human telomeric DNA is a hot topic in optical chemistry.2 By using the femtosecond broadband time-resolved fluorescence (fs-TRF), we find that one of the anti-parallel G quadruplex sequences HTD22A (5’-AGGG[TTAGGG]3) in sodium solution obtain a pure charge transfer state in ten picoseconds. The strong charge transfer character of G-quadruplex may be useful for applying in optoelectronics, molecular electronics, and nanotechnology.


  1. Y. Xu, Chemical Society reviews, 2011,40, 2719–2740.
  2. C. Ma, R. C. T. Chan, C. T. L. Chan, A. K. W. Wong and W.-M. Kwok, The Journal of Physical Chemistry Letters, 2019, 10, 7577-7585.


We highly appreciate financial support from the Research Grants Council of Hong Kong (15303018 and 15302319).

University: PolyU

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