Abstract

The emerging of bacteria with antibiotics resistance has become a new threat to human health in this world. Apart from the rational use of the existing antibiotics, development of antibiotics with new mechanisms to kill the bacteria is becoming more and more important.1. FtsZ is an essential protein in the cycle of bacterial replication. Without FtsZ, bacteria cannot complete the cell division. Thus, FtsZ has become an attractive target to inhibit the bacteria. PC1907232 is one of the ligands binding to the active site of FtsZ. Here taking PC190723 as lead compound, this research aims to develop a novel class of benzamide-skeleton compounds through inhibiting FtsZ protein to kill bacteria.

References

1. Bugg, T. D. H. Bioorganic Chemistry, 2014, 55, 1.
2. Hurley, K. A.; Santos, T. M. J Med Chem, 2016, 59, 6975-98.