Miss Shan Shan Ng


A palladium-catalyzed chemoselective borylation of (poly)halogenatedaryl triflates with a reactivity order of CCl > COTf is discovered. The catalyst system containing Pd(OAc)2 and SelectPhos shows a high reactivity and chemoselectivity. The consecutively chemoselective borylation reaction followed by the chemoselective intermolecular Suzuki-Miyaura reaction can be performed using a one-pot two-step approach to synthesize unsymmetrical biaryl compounds containing the triflate moiety. The reaction can be scaled up to the gram scale without diminishing the yield and chemoselectivity as well.


  1. Ng, S. S.; Chen, Z.; Yuen, O. Y.; So, C. M. Adv. Synth.Catal., 2022, 364, 1596 – 1601.

University: PolyU

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