Abstract

Biocompatible synthetic supramolecular systems have shed light on biomedical and tissue regenerative material applications. The intrinsic functional applicability, tunability, and stimuli-responsiveness of synthetic supramolecular systems allow to develop various multi-controlled supramolecular assembly in aqueous media. However, a single supramolecular system controls the degree of supramolecular polymerization, its structural transformation of morphology/helicity by multiple stimuli, and fabrication into biocompatible/functional macroscopic materials remains significantly challenging.1,2 Herein, we demonstrate a stiff stilbene amphiphile (SA) multi-controlled supramolecular assembling system with responsiveness to pH, ion strength, and light, and subsequently, assembled into macroscopic soft scaffold. This approach may allow cell attachment and photocontrolled biotarget release to provide a new strategy in fabrication of controllable/biocompatible soft scaffolds.

References

(1) Chen, S.; Yang, L.; Leung, F. K. C.; Kajitani, T.; Stuart, M. C. A.; Fukushima, T.; van Rijn, P.; Feringa, B. L. J. Am. Chem. Soc. 2022, 144, 3543–3553.

(2) Wong, W. K.; Lai, C. H. N.; Cheng, W. Y.; Tung, L. H.; Chang, R. C. C.; Leung, F. K. C. J. Compos. Sci. 2022, 6, 218.