Abstract

Sarcopenia, also known as muscle atrophy, is a progressive loss of skeletal muscle mass, quality and strength [1, 2]. Moreover, it also aggravates other chronic diseases resulted in increase of morbidity and mortality [3]. This study aims at examining the muscle atrophy improvement effect and the metabolic pathway of adipose-derived stem cell (ADSC) on dexamethasone (Dex) induced muscle atrophy rat serum based on UPLC-Orbitrap metabolomics analysis. After multi-variance analysis, features with high variable importance projection score (VIP>1.5) are selected and identified. The result shows that overall carnitine, fatty acid and glycophospholipid level is significantly increased in Dex model but all three classes are decreased after ADSC treated. Besides, carnosine which is important compounds in muscle have also been detected and show significant different between groups. The relationship between serum carnosine content and muscle atrophy is needed to further investigate.

Reference:

[1] M. J. Tallon, R. C. Harris etal., Biogerontology, 2007, 8, 129-137

[2] S. Kim, H.-S. Cheon etal., Osong Public Health and Research Perspectives, 2014, 5, 345-350

[3] S. Choi et al., Autophagy, 2019, 6, 1069-1081