Abstract 

This study aims at investigating the effect of piceatannol and resveratrol on bile acid profiles in high fat diet-induced hypercholesterolemic rats based on the bile acid content. Piceatannol is a metabolite of resveratrol, which is naturally available from grapes1 or traditional medicines of Polygonum cuspidatum2. Both piceatannol and resveratrol are the commercially available supplement, which would lower the level of cholesterol3. A study has indicated that piceatannol is associated with bile acids metabolism, thus reduces absorption of dietary cholesterol. Some deem that both piceatannol and resveratrol would be metabolized by gut microbiota4,5 , and suggest their therapeutic effect might be due to its interaction with gut microbiota. Since bile acids are the regulators of the gut microbiome, investigating its content would give an insight in gut metabolome on the effects of piceatannol and resveratrol. Using targeted mass spectrometry-based metabolomic platforms, a quantitative analytical method in bile acids have been developed. In conclusion, multivariate statistics on the bile acid content revealed the effect of piceatannol and resveratrol on the rate and their gut microbiome via bile acid profile. 

Reference: 

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